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I-Pyrogens, ekwabizwa ngokuba yi-endotoxins, iveliswa eludongeni lwe-extracellular ye-Gram-negative bacteria, oko kukuthi, iziqwenga zezidumbu zebhaktheriya.Yinto ye-lipopolysaccharide enobunzima bemolekyuli ukusuka kumawaka aliqela ukuya kumakhulu aliqela amawaka, kuxhomekeke kwiintlobo zebhaktiriya eziyivelisayo.Kwisisombululo esinamanzi, ubunzima bayo bemolekyuli bunokwahluka ukusuka kumakhulu amawaka ukuya kwizigidi
Ukuba umlinganiselo othile wepyrogen uxutywe iyeza uze utofwe kwinkqubo yegazi lomntu, oko kuya kubangela umkhuhlane omkhulu kunye nokufa.Ngoko ke, kubaluleke kakhulu ukunciphisa umxholo we-pyrogen kulwelo lwamayeza kangangoko kunokwenzeka, ngakumbi xa inaliti (efana nokufakwa okukhulu) idosi inkulu, imfuno yoxinaniso yepyrogen kufuneka ibe ngqongqo ngakumbi.

I-Depyrogenation yolwelo lwe-injection (okanye amanzi e-injection) likhonkco lokuvelisa elisisiseko kwishishini lamachiza ukwenza ukuba lihlangabezane nemigaqo yokuvavanya ye-Pharmacopoeia.Okwangoku, iindlela ze-depyrogenation zaziswa ngokubanzi kwezi ndidi zi-3 zilandelayo:

1. Indlela ye-distillation ivelisa amanzi e-depyrogenated, asetyenziswa njengamanzi okujova, ukuhlamba amanzi, njl., kodwa ixabiso layo liphezulu.
2. I-Depyrogenation ngendlela ye-adsorption.Enye yeendlela kukuba i-surface adsorbent ibhengeza izinto ze-pyrogenic kwaye ivumela izinto zemveliso ukuba zidlule.Indlela yesibini kukuba i-adsorbent ibhengeza izinto zemveliso kwaye ivumela i-pyrogen ukuba iphume.
3. Indlela yokuhlukanisa i-Membrane yokususwa kwe-pyrogen njengenkqubo entsha kwaye iteknoloji entsha iyathandwa kwaye isetyenziswe kumashishini amayeza.Umgaqo we-ultrafiltration ukususa i-pyrogen kukusebenzisa i-membrane ye-ultrafiltration encinci kunobunzima be-molecular ye-pyrogen ukuze ibambe i-pyrogen.Le ndlela iqinisekisiwe.Kwaye ineengenelo zokuxinana kwabasebenzi, imveliso ephezulu kunye nomgangatho olungileyo wemveliso.